Chronic muscle fatigue

Function of Skeletal Muscle

Skeletal muscle function was measured as force production and fatigue in both the quadriceps and adductor pollicis in five healthy volunteers, five patients with mild chronic heart failure, and five patients with rigorous chronic heart failure. The quadriceps of patients with chronic heart failure had an abridged muscle cross sectional area, a reduced maximum isometric force production and an increased tendency to fatigue. Isometric force production and fatigue of the adductor pollicis, however, were not considerably different between the three groups under control conditions. However during circulatory occlusion fatigue in the adductor pollicis is augmented more in the patients with severe chronic heart failure. These differing findings in quadriceps and adductor pollicis propose that skeletal muscle atrophy and reduced isometric force production are not an essential consequence of chronic heart failure per se, because they were only present in the large locomotive muscle.

Muscle Fatigue

The normal values for muscle fatigue experiential in adductor pollicis in patients with chronic heart failure imply that skeletal muscle blood flow must increase normally during muscle activation when only a small muscle mass is used. These results are not well matched with the concept of a generalized impairment of normal vasodilatation within active skeletal muscle. In contrast, activation of a large muscle, such as quadriceps, results into the rapid onset of fatigue in patients with severe chronic heart failure. This fatigue might be related to the inability of the cardiovascular system to provide the required blood flow for the activation of a large muscle mass. The finding of a relatively greater enhance in fatigue of adductor pollicis during circulatory occlusion in patients with severe chronic heart failure supports the hypnosis of an intrinsic abnormality of skeletal muscle in these patients.

Causes of Chronic Fatigue Syndrome

The causes of Chronic Fatigue Syndrome are as yet undetermined, but studies have shown that multiple nutrient deficiencies, food intolerance, extreme physical or mental stress might trigger chronic fatigue. Studies have also indicated that Chronic Fatigue Syndrome might be activated by the immune system, various abnormalities of the hypothalamic-pituitary axes, or by the reactivation of certain infectious agents in the body. Some Chronic Fatigue Syndrome patients have been found to have low levels of PBMC beta-endorphin and other neurotransmitters.

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